Glenn Quagmire from Seth MacFarlane's other show Family Guy makes an appearance in this episode, and he mentioned about making a cameo appearance in American Dad, MacFarlane's other show that is also set in Virgina. The Griffin family and Quahog also make an appearance. Donna also mentions other Family Guy characters whom Loretta had sex with, including, Frank Sinatra Jr., Ollie Williams, Mayor Adam West, and Greased up Deaf Guy.
Cleveland Jr. says that he mourned the loss of Loretta before she died. This happened in "Birth of a Salesman".
At the end of the episode, several clips from Family Guy appear.
Cleveland says, "No, no, no, no, no, no!!" when dropping his Oreo the same way he says it when he falls out of the bathtub in the Family Guy running gag.
When Cleveland is on the ferris wheel at the carnival, a character appearing similar to SpongeBob SquarePants is sitting next to him.