Donna makes reference to the fact that on most animated cartoon shows, the male protagonist has dozens of friends while the female protagonist has little to no friends. The examples she lists are herself, Marge Simpson, Lois Griffin, and Francine Smith.
Just after Peter bursts through the window he shouts "Leggo my negro", a reference to the slogan of Kellog's Eggo waffles "Leggo my Eggo".
Cleveland driving to Peter's house parodies a scene from Rocky IV when Rocky goes for a drive to clear his head after Apollo's death at the hands of Ivan Drago.
The scene at the end where Cleveland starts crying after Peter says "I know deep down in my heart, I still love you" is reference to a famous scene from the show Intervention that has become phenomenon on Youtube called "Best Cry Ever".